ROEMER, Klaus. MECHANISMS OF TUMORIGENESIS AND TUMOR SUPPRESSION

Current Pos: Associate (Apl.) Professor of Molecular Biology, Managing Director, José Carreras Research Center, University of Saarland Med School, Homburg, Germany.

Personal Data: b Kevelaer, NRW, Germany, October 22, 1959.

Educ: Univ of Bonn, Germany, MS, ‘84; Univ of Duesseldorf, Germany, PhD (Molecular Biology), ‘88.

Honors & Awards:  Fellow of the Fritz-ter-Mer Foundation, ’88; Fellow of the Studienstiftung des Deutschen Volkes, ’85-’88; Fellow of the German Academic Exchange Service, ’88-’91; Fellow of the German Research Foundation, ’91-’92; German Society for Muscle Diseases Award, 2000.

Prof Exp & Serv: Apl-Professor of Molecular Biology, Univ of Saarland Med School, ’06 to present; Senior Lecturer (Hochschuldozent), Institute of Virology, Univ of Saarland Med School, ’01-’05; Asst Professor, Institute of Virology, University of Saarland Med School, ’96-’01; Research Asst Professor, Center for Molecular Genetics, Univ of California San Diego, USA, ’92-’95; Postdoctoral fellow, Center for Molecular Genetics, Univ of California San Diego, USA, ’88-’92;
Acad Editor of PLoS ONE, '11 to present

Mem: Am Soc Biochem & Molecular Biol, ’94 to present; International Soc on Toxinology, ’04 to present; German Soc Biochem & Molecular Biol, ’08 to present; German Cancer Society, '11 to present

Res: Functions of the p53/p63/p73 family of transcriptional regulators. Functions of proteins encoded by Human Endogenous Retroviruses.

Contact: Phone: 49-6841-16-23091; email: klaus.roemer@uks.eu

• Heyne K, Conrad M, Dohmen D, Huwer J, Assmann G, Roemer K. Differential basal levels of MDM-2 transcription induced by p53-P72 and p53-R72. Cell Cycle 9:19, 4028-30, 2010.

• Roemer K. Are the conspicuous interdependences of fecundity, longevity and cognitive ability in humans caused in part by p53? Cell Cycle 9:17, 3438-41, 2010. (Perspective)

• Heyne K, Willnecker V, Schneider J, Conrad M, Raulf N, Schüle R, Roemer K. NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle. Nucleic Acids Res. 38(19):3159-71, 2010.

• Heyne K, Schmitt K, Mueller D, Armbruester V, Mestres P, Roemer K. Resistance of mitochondrial p53 to dominant inhibition. Mol Cancer 12;7:54, 2008.

• Bittenbring J, Parisot F, Wabo A, Mueller M, Kerschenmeyer L, Kreuz M, Truemper L, Landt O, Menzel A, Pfreundschuh M, Roemer K. MDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European Caucasians. BMC Cancer 23;8:116, 2008.

• Denne M, Sauter M, Licht JD, Roemer K, and Mueller-Lantzsch N. Physical and functional interaction between human endogenous retrovirus proteins Np9 and Rec and the Promyelocytic Leukemia Zinc Finger protein. J Virol 81: 5607-5616, 2007.

• Hublitz P, Kunowska N, Mayer UP, Müller JM, Heyne K, Yin N, Fritzsche C, Poli C, Miguel L, Schupp IW, van Grunsven LA, Poitiers N, van Dorsselaer A, Metzger E, Roemer K, and Schüle R. NIR is a novel INHAT-repressor that modulates the transcriptional activity of p53. Genes & Devel 19: 2912-2924, 2005.

• Galli UM, Sauter M, Lecher B, Maurer S, Herbst H, Roemer K, and Mueller-Lantzsch N. Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors. Oncogene 24:3223-3228, 2005.

• Mahyar-Roemer M, Fritzsche C, Wagner S, Laue M, and Roemer K. Mitochondrial p53 levels parallel total p53 levels independently of stress response in human colorectal carcinoma and glioblastoma cells. Oncogene 23:626-636, 2004.

• Mahyar-Roemer M, and Roemer K. p21Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents. Oncogene 20: 3387-3398, 2001.

• Prudlo J, Koenig J, Graeser J, Burckhardt E, Mestres P, Menger M, and Roemer K. Motor neuron cell death in a mouse model of FALS is not mediated by the p53 cell survival regulator. Brain Res 879: 183-187, 2000.

• Zlokarnik G, Negulescu PA, Knapp TE, Mere L, Burres N, Feng L, Whitney M, Roemer K, and Tsien RY. Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter. Science 279: 84-88, 1998.

• Sauter M, Roemer K, Best B, Afting M, Schommer S, Seitz G, Hartmann M, and Mueller-Lantzsch N. Specificity of antibodies directed against Env protein of human endogenous retroviruses in patients with germ cell tumors. Cancer Res 56: 4362-4365, 1996.

• Van Meir EG, Roemer K, Diserens A-C, Kikuchi T, Rempel SA, Haas M, Su-Huang H-J, Friedmann T, De Tribolet N, and Cavenee WK. Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles in glioblastoma cells. Proc Natl Acad Sci USA 92:1008-1012, 1995.